Metabolic fate of dietary sialic acid and its influence on gut and oral bacteria

In recent years, the biological functions of human milk oligosaccharides and potential toxic effects red meat on health have attracted considerable attention. Sialic acid is an important carbohydrate in meat, corresponding to sialylated N-glycolylneuraminic (NeuGc, one type sialic acid). Herein, we reviewed metabolic fate dietary body their gut oral microbes. summary, NeuAc monomer directly excreted through urine after being assimilated intestines not utilized by body; contrast, NeuGc from easily can be incorporated into brain other organs. Sialoglycans partially body, but they do affect cognitive development growth children. Dietary may mainly regulate metabolism gastrointestinal microbiota gut–brain axis.